12/25/2023 0 Comments Bacterial overgrowth breath testBreath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: an observation on non-absorbable antibiotics. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Diversity of the human intestinal microbial flora. Impact of pathogen burden in patients with coronary artery disease in relation to systemic inflammation and variation in genes encoding cytokines. Georges JL, Rupprecht HJ, Blankenberg S, et al. Lifetime risk of developing coronary heart disease. Lloyd-Jones DM, Larson MG, Beiser A, Levy D. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Mozaffarian D, Benjamin EJ, Go AS, et al. In the presence of risk factors, patients with SIBO may benefit from assessment for CAD. Further studies are necessary to confirm the association of SIBO with CAD. SIBO was found to be associated with CAD and with the number of coronary arteries involved in this study from a single tertiary center. In the stepwise multivariate logistic regression analysis, SIBO remained an independent risk factor for CAD (odds ratio 7.18, 95% confidence interval 3.09–16.67 p < 0.001). Patients with SIBO had an increased number of coronary arteries affected compared to SIBO-negative patients (1-vessel disease 67.2 vs. 12.9%, p = 0.025), use of angiotensin conversion enzyme inhibitor/blocker (45.5 vs. Patients with SIBO had a higher frequency of CAD (78.9 vs. Demographic, clinical, and laboratory variables and the presence of CAD on coronary angiography were analyzed. SIBO-positive patients were compared to SIBO-negative patients. In total, 160 had coronary artery angiography and were included in the study. MethodsĪ total of 1059 patients tested for SIBO using the glucose hydrogen/methane breath test from 2006 to 2014 were evaluated. To evaluate the frequency and risk factors for angiography-confirmed CAD in patients with or without SIBO. There is a lack of studies evaluating the association of small intestinal bacterial overgrowth (SIBO) with the development of CAD. A possible role of gut bacteria and their metabolic by-products in the development of coronary artery disease (CAD) is suspected.
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